Inzaghi was handed the reins at Milan last week, succeeding former team-mate Clarence Seedorf, who was relieved of his duties following the club's 11th-placed finish in Serie A.
It completes a significant step up for Inzaghi, having previously been in charge of Milan's youth team.
And Del Piero, who played alongside Inzaghi during Juventus' triumphant Serie A campaign in 1997-98, believes Silvio Berlusconi has taken a gamble, given the 40-year-old's limited experience.
"It's a big gamble that Berlusconi has taken but he has gone for a boy who eats, drinks, sleeps and dreams football," Del Piero said.
"I don't know how he will do as a coach because it's a new experience.
"It is a good challenge that Milan have decided to undertake. I wish him luck because I have won a lot with him."
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