Investigators in Naples said most of the games under scrutiny were from Italy's lower leagues but there were also several from Serie A.
"There has been an exchange of information with the FIGC (Italian Football Federation) over the games under suspicion," assistant prosecutor Rosario Cantelmo told Italy's Sky Sports 24.
"We have already contacted directors from the clubs involved for an explanation. At this moment we are not naming the clubs."
In June, Italy's Interior Ministry set up a match-fixing task force to explore ways of combating illegal betting in football after a criminal investigation which initially centred on 18 games in Serie B and Italy's lower divisions.
Police said they had found evidence of an organised system among former and current footballers, sports betting operators and others to manipulate the results of a number of matches.
Promoted Atalanta, one of the clubs investigated, were docked six points by the FIGC before the start of the Serie A season and club captain Cristiano Doni was suspended from football for three-and-a-half years.
In the Calciopoli scandal of 2006, which involved influencing the selection of referees, Juventus were demoted and stripped of the 2005 and 2006 Serie A titles, while AC Milan, Lazio, Fiorentina and Reggina were given points deductions.
The criminal trial into that affair is reaching its final stages in Naples, where prosecutors have requested a prison sentence of five years and eight months for former Juventus general manager Luciano Moggi.
