PARIS - Holders Olympique Lyon or Olympique Marseille will face a tough task away at Lille after the draw for the last 16 of the French Cup was made on Sunday.
Lyon take on Marseille on Wednesday in the final last 32 match after their previous game at amateurs Concarneau had been delayed.
There will be another all-Ligue 1 clash with a Brittany derby between Stade Rennes and Lorient.
Last year's finalists Paris St Germain will travel to third division Rodez.
The ties will be played on March 3 and 4, with the final scheduled at the Stade de France on May 9.