Just four players, including forward Freddy Adu, were kept from the squad in South Africa in a 23-man roster announced on Thursday including seven uncapped players.
The U.S kick off their defence of their regional title against Grenada on July 4 and face Honduras and Haiti before the knock-out stage.
Adu, Charlie Davies, Heath Pearce and Luis Robles were the four players from the Confederation Cup squad retained for the 12-team competition to be played at 13 venues across the United States.
All-time top scorer Landon Donovan and goalkeeper Tim Howard were among regulars left out.
United States Gold Cup Squad:
Goalkeepers: Jon Busch (Chicago Fire), Troy Perkins (IK Start), Luis Robles (Kaiserslautern)
Defenders: Steve Cherundolo (Hannover 96), Jimmy Conrad (Kansas City Wizards), Clarence Goodson (IK Start), Jay Heaps (New England Revolution), Chad Marshall (Columbus Crew), Michael Parkhurst (Nordsjaellands), Heath Pearce (Hansa Rostock)
Midfielders: Davy Arnaud (Kansas City Wizards), Kyle Beckerman (Real Salt Lake), Colin Clark (Colorado Rapids), Sam Cronin (Toronto FC), Brad Evans (Seattle Sounders), Stuart Holden (Houston Dynamo), Logan Pause (Chicago Fire), Robbie Rogers (Columbus Crew)
Forwards: Freddy Adu (AS Monaco), Brian Ching (Houston Dynamo), Kenny Cooper (FC Dallas), Charlie Davies (pictured) (Hammarby), Santino Quaranta (D.C. United)
