Olmes Garcia's header and a delightful chip from Juan Manuel Martinez saw Real Salt Lake win their third CONCACAF Champions League match.
Santos Laguna won Group A and secured a quarter-final berth, while reigning champions America confirmed their spot in the knockout round.
America started their CONCACAF Champions League defence in fine fashion, earning just their second win in 10 matches.
A tragic stampede ahead of the Clausura final between Motagua and Progreso cost four fans their lives.
Wilson Lalin was the match-winner for Comunicaciones, while Motagua also moved off the bottom of their CONCACAF Champions League group.
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