The North African giants find themselves bottom of Group G, six points behind joint leaders Senegal and Tunisia, and with the same record as lowly Botswana who they travel to face on Friday night: played two, lost two and a minus-three goal difference.
Anything but a win will pile pressure on Egypt coach Shawky Gharib who has been told by the Egyptian Football Association (EFA) president Gamal Allam that he will be fired if he cannot guide his team to the tournament in Morocco.
"The national team's failures are the responsibility of its technical staff. We will hire a foreign manager if Gharib fails to take the team to Morocco," Allam declared last week.
Egypt's plight is not helped by four players missing due to injury: Al Ahly goalkeeper Sherif Ekramy, Zamalek winger Hazem Emam, Smouha attacker Hany El Egiazy and Hull City winger Ahmed Elmohamady.
"I know that we are not in a good situation after losing the first two matches, but we still have hope to qualify. We will do our best in the next matches," Gharib added.
Another pedigree team who find themselves languishing bottom of their group are Angola.
AFCON quarter-finalists in 2010, Angola travel to Lesotho desperate for their first points in Group C after an away defeat to Gabon and a 3-0 home thumping at Burkino Faso's hands.
However, coach Romeu Filemon will have to unlock his squad's goal scoring potential after a measly return of one goal in their last four matches.
Three giants of African football are fighting it out in Group D as leaders Cameroon also look to maintain a 100 per cent record against winless Sierra Leone in Freetown.
Third-placed Ivory Coast are looking to bounce back against Democratic Republic of Congo after their 4-1 humbling by Cameroon in the previous round. Anything less than a draw will leave Herve Renard's men adrift of the group's pacesetters and under pressure in their remaining matches.
A big day in Group A sees South Africa face surprise leaders Congo who have already beaten Nigeria away and Sudan at home.
"We are all well prepared for Congo and we will not be affected by the artificial surface. The way we play will remain the same," said Meyiwa.
"At Orlando Pirates, we played on a similar surface during the CAF Champions League. It is likely to be the same."
In Group E, second-placed Ghana travel to Guinea looking to put some daylight between them and the team in third, while table-toppers Uganda welcome winless Togo to the Mandela National Stadium in Kampala looking for another three points.
