Bale – who has been the subject of public interest from Spanish giants Real Madrid over the close-season – is suffering pain in his foot that will keep him out of the club's season opener at Selhurst Park this weekend.
Real are reported to have made a world-record transfer bid for Bale and the 24-year-old may have played his last match for Tottenham, with Villas-Boas expecting him to be sidelined for a number of weeks.
The Portuguese manager was asked if Bale would play on Sunday and responded: "No, because he has been out injured for most of the pre-season.
"He was involved in the games that we had against Brentford and Swindon but not any more for different reasons.
"He pulled a muscle on his gluteus that prevented him from being involved for two weeks.
"He has been complaining with pain in his foot. I think the most natural thing is for us not to involve him in this new game coming against Palace."
