A free-kick from Ivan Rakitic in the 12th minute got Barcelona underway at Huesca's Estadio El Alcoraz before Andres Iniesta and Pedro also scored before half-time, while Rafinha's 71st-minute strike wrapped up the first-leg victory.
With a number of younger players in the starting line-up, including Douglas Pereira, Marc Bartra and Sergi Samper, Luis Enrique paid tribute to Barcelona's professionalism and commitment against their Segunda B opposition.
"These games can become difficult," he said.
"Even though the pitch was in perfect state to play in, sometimes the opponents are more motivated than we are.
"But I think that we were really intense and we played a really serious game.
"I think in the first half we decided the tie and in the second half we were a bit more up and down but you can understand that."
