Dortmund travel to the Allianz Arena buoyed by their 2-0 victory over Real Madrid in the UEFA Champions League on Tuesday, despite going out of the competition 3-2 on aggregate.
They sit second in the German top flight, three points ahead of arch-rivals Schalke in third, and can strengthen their grip on the position with victory against the newly crowned champions.
The manager decided to rotate ahead of Bayern's quarter-final in Europe's premier club competition, a decision that paid dividends as they beat Manchester United 3-1 on Wednesday, allowing them to progress to the last four with a 4-2 aggregate triumph.
"This is a sensational time to play Bayern, between Real Madrid and Wolfsburg," he said.
"In recent weeks the deciding moments have gone against us, and we've been short of a little bit of luck.
"This is about collecting three important points which could do us a world of good."
Dortmund's regular injury worries this season have not eased - Neven Subotic, Jakub Blaszczykowski (both knee), Marcel Schmelzer and Sven Bender (both groin) remain out - but captain Sebastian Kehl returns from suspension.
