Pep Guardiola's men - now 48 matches unbeaten in the league - currently sit 20 points clear at the top of the German top flight having won 21 of their 23 matches this season, but Wolfsburg have the potential to provide tricky opposition.
Dieter Hecking has put his side in contention for a UEFA Champions League spot, sitting just six points adrift of second-placed Borussia Dortmund.
However, last weekend's shock 6-2 defeat at mid-table Hoffenheim halted Wolfsburg in their tracks after a run of four consecutive wins in all competitions.
Wolfsburg have only managed to find the net on three occasions in nine subsequent league meetings with Bayern, failing to score in the last five.
"For me, a home game against Bayern is the game of the year," he told the club's official website. "We need to show just what we are capable of.
"We are not just going into that game to sit back and watch how good the opponents are.
"Why must we lose against Bayern Munich? We are Wolfsburg, we are playing at home.
"Bayern are strong, but we have our own qualities too and we have proven that often enough."
Christian Trasch serves the first of a two-game suspension for Wolfsburg after being sent off against Hoffenheim.
