Aitor Karanka's men, who sit third, played one of the main roles in a fourth round of FA Cup shocks last week.
Middlesbrough won 2-0 at Premier League champions Manchester City, with second-half goals from Patrick Bamford and Kike sealing their place in the last 16.
Another tricky trip awaits them - this time at Arsenal - but the North-East club are in the mood to beat anyone.
That has seen them rise up the Championship table, just a point behind leaders Bournemouth and with a spot in the top two potentially on the line on Saturday, striker Bamford is confident his side can win again.
"I think we've shown that if we get up there to the Premier League, we're a match for anyone," he told Middlesbrough's official website. "First Liverpool [in the League Cup], we lost on penalties…and then again on Saturday against Man City.
"It takes a lot of concentration but when we stick to our game plan, we can do well."
Mark Warburton's side are just one point behind Middlesbrough and have won seven of their last nine home fixtures in the Championship.
Just three points below Watford in seventh are Wolves, who are unbeaten in seven in the Championship - with five of them being wins.
Kenny Jackett's side go to the Macron Stadium to face Bolton Wanderers on Saturday. Bolton added to their strike power with the loan signing of Adam Le Fondre, from Cardiff City, earlier this week.
Neil Redfearn will look to build on Leeds' surprise win against the table-toppers when they visit Huddersfield Town in a Yorkshire derby.
The last five meetings between the two sides have seen 23 goals scored, with new signings Sol Bamba and Granddi Ngoyi set to be in the mix for United.
