Chelsea laboured to a 1-1 draw with Atletico Madrid which has serious ramifications for their Champions League last-16 fixture.
The Blues needed a win to guarantee top spot in Group C but found Atletico goalkeeper Jan Oblak in inspired form before Saul Niguez nodded in with an effort that looked like it might seal a win for Diego Simeone's side, themselves needing maximum points to have any chance of going through.
Roma beat Qarabag 1-0 in the Eternal City, however, to deny both teams here, eliminating Atletico and giving Antonio Conte cause for concern after his side could not add to Stefan Savic's own goal.
With English clubs topping four of the other seven groups, as it stands Conte's men would face Besiktas, Barcelona or Paris Saint-Germain in the next round.
The latter sides would likely send panic through Stamford Bridge. PSG eliminated Chelsea in their last Champions League campaign in 2016, but the Blues have not played Barca since the semi-final win over the Catalans en route to the title in 2012.
Though Atletico are notoriously difficult to beat, Conte will be concerned after Chelsea failed to score with 17 shots on goal. Such wastefulness will not help the Italian finally leave an imprint on this competition come the new year.
Atletico started with the intensity of a team needing to win, but Fernando Torres' deflected effort and a lashed Thomas Partey shot cleared the bar in the sum of their efforts.
Lucas Hernandez was destroyer-in-chief whenever Eden Hazard took possession but the Frenchman earned a booking and a warning from referee Danny Makkelie for fouls on the Belgian, which curtailed the rough stuff and allowed Hazard greater room to operate.
Former Real Madrid man Alvaro Morata curled wide and twice tested Oblak, first off-balance from close range and then from an angle, but Hazard ought to have done better when he scuffed harmlessly from 15 yards when picked out well by Tiemoue Bakayoko.
Oblak was again put to work by Davide Zappacosta's low drive as Chelsea continued to dominate to the break and the Blues began the second half with Morata, Hazard and Andreas Christensen going close before Atletico suddenly pounced.
Filipe Luis hit the post from 25 yards, but news soon filtered through that Roma had taken the lead, which led to stern celebrations from Simeone when Saul peeled off Bakayoko to convert Torres' flick-on inside the six-yard box.
Cesc Fabregas routinely found space right up on the Atletico byline and one such raid ought to have been converted by Christensen, but the defender bundled wide from inches out.
The goal finally arrived 15 minutes from the end, Hazard a predictable source as his fizzing cross was too quick for Savic, whose unorganised feet directed the ball high past Oblak.
The goalkeeper sprung from his line barely a minute later to smother Morata one-on-one and an unmarked Willian blazed over to leave Conte chewing over a likely heavyweight contest in the first knockout round.
