Mario Salas' Huachipato eased past Nublense at the Estadio CAP in the opening round of the 2014 season on Sunday.
Two goals in the first half from Francisco Arrue and Argentinean Lucas Simon set the tone before Martin Rodriguez sealed the result with 26 minutes remaining in Talcahuano.
At the Estadio Elias Figueroa Brander, Roberto Gutierrez's first-half brace inspired home side Santiago Wanderers to a resounding win over Barnechea on Saturday.
Gutierrez scored two goals in three minutes before the half-time interval and Argentina's Jorge Luna capped the dominant performance with a goal of his own on the hour-mark.
Cobresal's woes were compounded in the 88th minute when Patricio Jerez was sent off for a second bookable offence, though the visitors salvage some pride with a late goal from Carlos Escobar.
Defending Apertura champions O'Higgins kicked off their title defence with a 2-1 win at Union La Calera.
Chilean powerhouses Colo Colo could only salvage a 1-1 draw at San Marcos after Esteban Paredes' 68th-minute penalty secured a share of the spoils.
