Palmeiras booked their spot in the Copa Libertadores knockout rounds, while Nacional claimed their first win of the group stage on Wednesday.
Goals from Keno and Lucas Lima saw Palmeiras record a 2-0 victory over Boca Juniors in Buenos Aires.
Estamos voltando de com a classificação na mala!Garanta o manto do April 26, 2018
In Group Six, Nacional recorded a much-needed 4-0 win over Real Garcilaso in Montevideo.
A 25-yard free-kick from Sebastian Rodriguez put the hosts ahead before they struck three times in the final 10 minutes.
Guzman Corujo headed in Nacional's second before Leandro Barcia and Gonzalo Bergessio sealed the victory.
Nacional superó 4-0 a Real Garcilaso y escaló al segundo lugar del Grupo F de 2018. April 26, 2018
Nacional climbed into second in the group on five points, four behind Santos and one clear of Estudiantes and Real Garcilaso.
In Group One, Monagas stunned Defensor Sporting 1-0, while Atletico Tucuman cruised past The Strongest 3-0 in Group Three.
Flamengo and Santa Fe played out a 0-0 draw in Bogota in Group Four.
