The Chilean teams suffered first-leg losses and face a battle to advance in the second most prestigious South American club competition.
An out-of-form Catolica travel to Montevideo to face River Plate, who claimed a 1-0 win in Santiago de Chile.
"We're going to lift the mood. We have to get up. We trust our decisions and our work," he said.
It appears even tougher for Iquique, who were beaten 2-0 at Club Universitario in the first leg and host Tuesday's second leg.
Elsewhere, Cerro Porteno are well-placed to progress ahead of their second leg against Uruguay's Rentistas.
Thanks to Andres Vilches' first-leg brace, Chileans Huachipato take a 3-1 lead to San Jose in Bolivia.
Also locked at 1-1 are Emelec and Colombia's Aguilas Doradas ahead of their second leg in Ecuador.
Bolivia's Nacional Potosi visit Paraguay's Libertad with a 1-0 lead, while General Diaz go to Cobresal with a 2-1 advantage.
Deportivo Cali host UTC Cajamarca after a 0-0 draw in the first leg and Uruguay's Penarol go to Bolivia's Wilstermann leading 2-0.
Venezuelans Deportivo La Guaira and Colombia's Atletico Nacional are locked at 1-1, with the latter hosting the second leg.
