Claudio Ranieri's side have made an unbeaten start to their Ligue 1 campaign, extending that run with a 2-1 against Lyon on Sunday, and they will look to take that form into the cup fixture at the Stade Auguste-Delaune.
They will be keen to improve on last year's performance in the competition, when they suffered a 2-1 home defeat to Troyes in the round of 16, as they go in search of a second trophy success in the tournament, having defeated Sochaux 4-1 in the 2003 final.
Jean Fernandez's charges enjoyed a run to the semi-finals last season, but they were denied a place in the final courtesy of a 2-0 defeat away to Rennes.
Wednesday also sees an all-Ligue 1 encounter between Guingamp and Evian at the Stade du Roudourou.
However, Rene Girard's side face a potential banana skin in Tuesday's tie against second-tier side Auxerre, who have seen off Brest and Caen to reach round three.
There is at least one side from outside the top level of French football guaranteed to be involved in the next round, as Ligue 2's Tours play host to Amiens of the Championnat National.
