Ferguson praised the pair after United shook off an early Fernando Torres goal to beat Liverpool 2-1 at Old Trafford and return to the top of the table.
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"Wolves put it in our face, every ball was pumped forward and they challenged for everything, it was a real battle," Ferguson said.
"But what I thought then was that Vidic and Ferdinand coming back from a long time off, they rose to that challenge.
"They were fantastic, they were saying 'this is my type of game' and after that I said to myself 'keep those two fit and we've a marvellous chance against anyone'. Vidic today, in particular, was absolutely magnificent.
"So we have a very experienced back four and a very experienced goalkeeper and it gives us an outstanding chance, albeit there are seven difficult matches left."
However, the two have played together in United's last four matches with Torres's strike the only goal they have conceded.
"I thought it was a red card," Ferguson said.
"I don't see how anyone could have stopped Valencia from shooting and that's a goal scoring opportunity as far as I am concerned."
