Xabier Azkargorta's side have endured a disappointing campaign in the South American qualifying section, with just two victories taken from their 15 fixtures.
They sit bottom of the pool, one point behind eighth-placed Paraguay, but could restore some pride by taking maximum points against Sergio Markarian's men at the Estadio Nacional de Lima.
If Bolivia do pick up their third win of the campaign and Paraguay fail to beat second-placed Colombia in Asuncion, they would at least avoid the ignominy of propping up the final standings.
However, Azkargorta's team are on a run of eight games without victory, with their last win coming in a 2-1 friendly triumph over Haiti in February.
There were signs of improvement in a 1-1 draw at home to Ecuador in their last qualifier though, when they were only denied a win as Felipe Caicedo's penalty cancelled out Jaime Arrascaita's opener.
Markarian's side have gone five matches without victory, and have lost their last three matches in a row.
Their latest fixture saw them take an unlikely 1-0 lead against Argentina through Claudio Pizarro's 21st-minute strike last Friday.
