The forward sustained the injury in Real's 0-0 draw at Real Mallorca on the opening day of the season and missed Portugal's European qualifiers at home to Cyprus and away to Norway.
"He'll play," Mourinho told a news conference on Friday after Ronaldo successfuly completed a training session at the club's facility on the outskirts of the Spanish capital.
"He's in good shape and because it's a difficult match he'll play from the start."
The Brazil playmaker told Real's website his recovery was progressing well.
"I have no pain in the knee," he said. "It's a month now since the injury and everything is going well. I am doing many hours of physiotherapy and that's helping me a lot."
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