Arsene Wenger's side have found remarkable consistency since the 6-3 loss at title rivals Manchester City in December, claiming seven consecutive triumphs in all competitions.
That run has left the London club fighting for silverware on three fronts, and has also silenced the doubters, who suggested that Arsenal's Etihad mauling would spell the end of their championship challenge.
Wenger's charges have not lost to Southampton since November 2002, but can expect a stern test at St Mary's as they attempt to stretch their lead at the top of the table, with City and Chelsea not in action until Wednesday.
The forward could be back on the substitutes' bench against his former club, but he is relishing the prospect of returning to the south coast once again.
He told the club's official website: "To go back there in any sense is always really nice, especially when we go to play them.
"Last season I went back there and it was a surreal feeling for me, warming up on the opposite side of the pitch and being in the opposite dressing room.
"It was the first time I went back there to play so it was a bit weird for me. I'm looking forward to going back this season, obviously they're doing really well so it's a tough game for us."
Southampton have won their last three home games and striker Guly do Prado warned Arsenal not to expect an easy ride after scoring in Saturday's FA Cup win over Yeovil Town.
"We get confidence from these wins," the striker told the club's official website. "We play for a win in every game, whether it’s in the FA Cup or the Premier League.
"The win today will give us confidence for Tuesday night against Arsenal. Now we have to think about that because it's going to be another big, hard game – but we are going to play to win."
