Scotland international McGregor has picked up a shoulder injury and Bruce will monitor his first-choice keeper before the KC Stadium clash.
McGregor was at fault on Thursday as Hull lost 1-0 at Lokeren in their UEFA Europa League play-off first leg - his poor clearance allowing Hans Vanaken to score the only goal of the game.
"McGregor is a bit of a worry as he has hurt his shoulder," said Bruce.
"But everybody else is okay. We made nine changes the other night so hopefully we'll be fresh enough. To win a game in the Premier League your performance has to reach a certain intensity, so we have to be fresh enough to reach that.
"To get back to back wins in the Premier League would be great. I don't think we've done that for about a year so it shows how hard it is."
