Vicente del Bosque's men are the reigning World and European champions and currently sit atop the FIFA world rankings.
Equatorial Guinea, meanwhile, are 119th and without a victory in five matches. Their highest ranked opposition in that run was Tunisia, who sit 47th.
Diego Costa - Atletico Madrid's Brazil-born forward who was tipped to make his debut for Spain - has been forced to withdraw from the squad with a torn muscle in his right leg, and he joins Cesc Fabregas (knee) on the sidelines.
"Our national team is feeling full of confidence, with a great deal of desire," Ramos is quoted as saying by Eurosport.
"We managed it before (winning the World Cup) and who's to say we cannot repeat that success.
"We cannot live on past achievements, there is no point dwelling on them, instead we want to repeat them."
