Carlo Ancelotti's side are in a fine run of form in the Spanish top flight, with defending champions Barcelona the last side to claim three points against Real on October 26.
Real have been particularly dominant on home soil in the league, winning eight of their nine home fixtures, with city rivals Atletico the only side to leave the Bernabeu with maximum points.
The recent purple patch has seen Real close the gap to leaders Barca and second-placed Atletico to just one point and Ancelotti's men will be buoyed by a 5-0 demolition at Real Betis last Saturday in their last league outing.
That rout was followed by a 1-0 triumph at Espanyol in the first leg of the Copa del Rey quarter-finals on Tuesday, when Benzema notched the game's only goal in the 25th minute.
Granada's last two visits to the Bernabeu resulted in 5-1 and 3-0 defeats and a poor return of just 19 goals in 20 top-flight matches makes their task seem even more difficult.
However, Granada have proved stern opposition for La Liga opponents this season, with Lucas Alcaraz's men losing on just three occasions on their travels in the league.
