Both sides are likely to, along with Villarreal, battle it out for the fourth and final UEFA Champions League berth in Spain's top flight this season.
While La Liga leaders Real Madrid are only six points ahead of the fourth-placed Sevilla, it appears likely that Carlo Ancelotti's men will finish in the top three, alongside Barcelona and defending champions Atletico Madrid.
Sevilla knocked Valencia out of the UEFA Europa League semi-finals last term, needing a stoppage-time goal from Stephane M'Bia in the second leg to send them through to the showpiece.
"Every game is a big deal to us but there are some that [are] more special" Gomes told Valencia's official website ahead of the match.
"It's going to be a fight to the finish against Sevilla and a few other teams until the end of the season.
"Sevilla are not the only big rival we have. The important thing is that we have the mentality to win.
"The second half of the season is just beginning. It is essential to be in winning form and get three points."
Luis Enrique's men, who beat Atletico Madrid 1-0 in their Copa del Rey quarter-final first leg on Wednesday, go to Elche.
Barca defeated Elche 9-0 on aggregate in the Copa del Rey's last 16 earlier this month.
