Laurent Blanc's side moved five points clear at the top of the table by beating bottom-of-the-table Ajaccio last weekend.
The champions' grip on top spot was strengthened as second-placed Monaco drew with Montpellier and Lille, who sit third in the table, were beaten at home by Reims.
PSG followed that up with a 3-1 win at Bordeaux in the Coupe de France on Tuesday night, with late goals from Adrien Rabiot and Blaise Matuidi setting up a semi-final against Sunday's opponents Nantes.
Not since October 2004 have Nantes beaten PSG in the league, but they will see this as an opportunity to strike a psychological blow ahead of next month's semi-final.
Filip Djordevic scored twice as Michel Der Zakarian's side beat Nice 4-3 in a Coupe de France thriller on Wednesday night.
And Der Kakarian is eyeing another strong showing against Blanc's title favourites.
He said: "We play Paris and, even though they have huge options, everything is possible in football.
"The team must believe it. I have a hunch, I sense that we are going to be centre-stage across France.
"We will be in a fight, but in a game, everything is possible. With this state of mind on display, I sense we can do well."
