The Stade Auguste Bonal club claimed a 0-0 draw on the final day of last term in Corsica, which proved enough to ensure survival as Nancy, Troyes and Brest fell into the second tier.
Herve Renard's men will be desperate to go one better at the Stade Armand Cesari this time around.
Evian's stunning 1-0 win over second-placed Monaco last time out significantly enhanced their prospects of remaining in the top flight.
And Pascal Dupraz's men could take another step towards safety with a victory at Lorient, who are not yet sure of their place in Ligue 1 for next term.
Claudio Ranieri's men currently hold a nine-point advantage over fourth-placed Saint-Etienne and host a Nantes side unbeaten in four.
Saint-Etienne's immediate target is overhauling third-placed Lille, with only three points separating the two sides heading into the weekend.
Lille's trip to Toulouse pits two in-form teams against each other as Rene Girard's men look to make it nine league games unbeaten against a home side without a defeat in five.
Jose Anigo's side took just two points from five games in March, a run that has left them nine points adrift of a European place and one that forward Andre Ayew attributes to Marseille's lack of experience.
"I think when you buy young players in a club like Marseille, with a lot of pressure, some players can cope with it no problem, and some others need time," Ayew told BeIN Sport.
"That's why there are a lot of ups and downs, and we need to be more consistent."
