The left-back has missed each of the last two games with a thigh problem, and faces a race to be fit for the visit to the Britannia Stadium.
"We're going to assess him today and make a final decision. It is a difficult one," Roberto Martinez said in a press conference on Tuesday.
"Apart from Leighton, there are no other injury worries. It is the same squad which went to Arsenal."
"We are not in a position to look back too much," he said.
"Yes we are not getting the results we all want but what we have now is a great opportunity to go into the last 11 games and create some momentum.
"That is the focus rather than highlighting a statistic because statistics can be used any way you want.
"We need to be able to perform well and overcome the small margins.
"Sometimes you can assess a performance through a scoreline, the black and white of a 2-0 defeat to Arsenal, but those who watched the game would have seen we were very close to getting a positive result in that game.
"It is a moment in the season when all that is needed is simplicity: which is preparing for the game ahead to make sure we get a positive result."
