The Everton midfielder made 43 appearances for club and country this season and will be afforded a rest for the fixtures against Turkey, Italy, Costa Rica and Portugal.
Joey O'Brien and Darren Randolph have also been cut from coach Martin O'Neill's initial 32-man selection.
O'Neill revealed when the full squad was announced earlier this month that he had contacted the playmaker over a return to the international arena.
Ireland take on Turkey at the Aviva Stadium on May 25, before facing FIFA World Cup hopefuls Italy at Fulham's Craven Cottage home.
O'Neill's side will also test their mettle against World Cup sides in the shape of Costa Rica and Portugal, with both of those games to be played in the United States.
Squad in full:
Defenders: Ciaran Clark (Aston Villa), Seamus Coleman (Everton), Damien Delaney (Crystal Palace), Shane Duffy (Everton), Stephen Kelly (Reading), Richard Keogh (Derby County), John O'Shea (Sunderland), Alex Pearce (Reading), Stephen Ward (Brighton and Hove Albion), Marc Wilson (Stoke City)
