Pato is involved in negotiations for a move to world club champions Corinthians and Robinho has also been the subject of speculation over a return home with his former club Santos among the contenders.
"I hope that only one of them leaves," Berlusconi told Radio Lombardia. "I'm especially sorry about Pato because until he started this incredible sequence of injuries, he was Milan's number one player for the future, a true champion."
Pato, signed as a 17-year-old and now 23, has suffered an extraordinary 16 muscular injuries in the last two years, costing him, among other things, a place in Brazil's squad at the 2010 World Cup.
"We must devote ourselves to a work of rebuilding and I believe will not be less than three years before we get to the point where we have a team champions and turn ourselves into contenders again," he said.
