Andrea Pirlo is set to make his New York City debut and Frank Lampard could do likewise when their team face Orlando City.
All eyes will be on Yankee Stadium on Sunday with two stars potentially taking the field in MLS for the first time.
Pirlo departed Italy for the United States days ahead of the clash, fresh from his Serie A-winning campaign with Juventus.
Lampard has battled a calf injury, which has delayed his debut, but he is nearing a return to fitness for Jason Kreis' men.
New York City are growing increasingly desperate, sitting second-bottom in the Eastern Conference and three points off sixth-placed Orlando.
While Orlando have been led by nine league goals from Kaka, they have been in a worrying run of form that has included just one win in their past five MLS outings.
Bruce Arena's Galaxy have scored 20 goals in their past five league outings on their way to second in the Western Conference.
Eastern Conference leaders DC United will be out to end a two-game losing league run when they host the Philadelphia Union.
Real Salt Lake and Sporting Kansas City open the latest round of fixtures on Friday, while the Columbus Crew host Toronto, the Seattle Sounders take on the Montreal Impact and the Chicago Fire are at home to the New England Revolution.
