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The Royal Dutch Football Association (KNVB) released a statement on Sunday confirming the duo had been withdrawn from Guus Hiddink's 25-man squad that had been selected for European 2016 qualifiers versus Kazakhstan and Iceland.
Neither played any part in their country's 3-1 win over the Kazakhs on Friday with reports indicating Newcastle United goalkeeper Krul has suffered an elbow injury, while Wijnaldum has hurt his knee.
Hiddink has selected Feyenoord's Kenneth Vermeer to cover Krul's absence and Erik Pieters of Stoke City joins the squad in place of Wijnaldum.
