Defender Jamie Carragher is set for his 600th appearance for Liverpool against Portsmouth on Saturday, becoming only the ninth player to reach that milestone for the club.
"To be at one club for such a long time and to play 600 games is absolutely amazing and shows the passion and commitment," said manager Rafa Benitez.
United's Dutch goalkeeper Edwin van der Sar will not be available to face his former club and has flown to the Netherlands to see the national team doctor about his knee injury.
Manager Alex Ferguson also said defenders John O'Shea and Jonny Evans and midfielder Owen Hargreaves are not expected back until "well into January".
Manchester City manager Mark Hughes has told his players they must regain the form that saw them beat leaders Chelsea and Arsenal when they host Sunderland, led by Hughes's former Manchester United team mate Steve Bruce, on Saturday.
Blackburn Rovers have Australian midfielder Vince Grella back for Saturday's home game against Tottenham Hotspur after illness. However, Brett Emerton (groin) and David Dunn (calf) are both unavailable.
"I have had some great moments here and I want to do more, play more games and bring more trophies," he told the club website.
Everton midfielder Jack Rodwell has joined the club's lengthy injury list after suffering a suspected hamstring injury in the club's Europa League defeat to BATE Borisov on Thursday.
However, Australian international Tim Cahill returns from suspension for Sunday's match
