Coach Leonardo has the dilemma of whether to give Ronaldinho another chance to find his old form with a starting place in stuttering AC Milan's home match against Bologna on Sunday.
The playmaker was inspirational in mid-table Milan's opening-day victory at Siena but was then ineffective in the 4-0 derby defeat by Inter and in last weekend's goalless draw at Livorno.
Leonardo may be tempted to use Clarence Seedorf, who set up Filippo Inzaghi's double in Tuesday's 2-1 Champions League win at Olympique Marseille.
But dropping Ronaldinho again after he was regularly sidelined by former boss Carlo Ancelotti last season risks crushing the Brazilian's confidence as he could read it as a definitive thumbs down.
Genoa, who have a 100 percent record as well, will visit Chievo Verona on Sunday without Domenico Criscito after the defender was given a two-match ban for being sent off for dissent in Sunday's 4-1 win over Napoli.
Midfielder Andrea Poli is favourite to take suspended Fernando Tissone's place when Genoa's city rivals Sampdoria defend Serie A's other spotless record at home to Siena on Sunday.
Esteban Cambiasso could come off the bench to get his first slice of competitive action since suffering a knee injury in August in champions Inter's away match in Cagliari on Sunday.
The Argentine midfielder was an unused substitute for Inter, who are two points behind the leading trio, in Wednesday's 0-0 draw with Barcelona in the Champions League.
New AS Roma coach Claudio Ranieri has his work cut out to fix the defensive problems exposed in Thursday's 2-0 Europa League defeat at Basel before they host Fiorentina in Sunday's late game.
The visitors should have Alberto Gilardino back up front after the Italy forward was sent off in the first half of Wednesday's 1-0 defeat at Olympique Lyon in the Champions League.
A minute's silence will be observed before all sporting events in Italy this weekend after six Italian soldiers were among the victims of a bomb attack in Afghanistan on Thursday.
