The Borussia Dortmund forward missed the matches with the Republic of Ireland and Poland last month, but he has since recovered fully and earned a place in Joachim Low's 23-man squad.
Germany, who are third in UEFA Euro 2016 qualifying Group D after a draw with Ireland and defeat to Poland, face Gibraltar on November 14 in Nuremberg before travelling to Vigo for a friendly against Spain.
Low is looking forward to welcoming the quartet back and has also handed a first call-up to Cologne defender Jonas Hector.
"The returnees Marco Reus, Sami Khedira, Benedikt Howedes and Lars Bender will do us good," Low said.
"They are, despite their young age, already experienced players for us.
"We want Jonas Hector to become better acquainted [with the national team], he has been in good form for Cologne.
"We go with a broad squad in the two games and would like to choose the possible positive year against Gibraltar, we want to achieve a clear victory in the European Championship qualifier on home soil against the current and previous European and to play world champions Spain is always something special."
Hoffenheim striker Kevin Volland is also back in the squad after making his debut against Poland earlier this year. He featured for Germany's Under-21 side last month, scoring in both legs against Ukraine to seal a place in the Under-21 European Championships.
Squad in full:
