The 24-year-old was part of the squad convincingly beaten by Arsene Wenger's side in September 2012, although the visitors were already 5-1 down when Rodriguez came off the bench.
That loss at the Emirates Stadium was their heaviest during their comeback season in the top flight, and Rodriguez admitted the pain was still there over a year later.
"Last year was a nightmare to get beat 6-1 there," he told the club's official website. "But we've got a point to prove and we'll go there looking to do that.
"Of course I'm looking forward to that game, it's going to be a great game and we're going to take it to Arsenal so it’ll be a great occasion."
A third away victory of the campaign for Mauricio Pochettino's side would see them move level on points with the league leaders.
