Cristiano Ronaldo will be hoping to build upon his formidable away form in the Champions League at Legia Warsaw, while Leicester City - amid exalted historical company - are on the brink of progression.
Expect plenty of goals when Sporting CP visit Borussia Dortmund, with Pierre Emerick-Aubameyang certain to be a threat.
With the help of Opta, we bring you the best stats for Wednesday's Champions League group stage fixtures.
47 - Real Madrid have failed to score only once in their last 47 Champions League group games.
28 - Cristiano Ronaldo has scored 28 times in his 23 Champions League appearances away from home for Madrid.
61 - Borussia Dortmund have had more shots than any other team over the first three games in this season's group stages: 61. Only Barcelona (13) have scored more goals than BVB (10).
5.8 - Sporting CP's last five Champions League games against German clubs have produced 29 goals, an average of 5.8 goals per game.
14 - Juventus fullback Dani Alves has created 14 chances this season in the Champions League; three more than any other player.
1 - Tottenham have failed to score more than one goal in their last seven Champions League games and in this season's group stage, only two of Spurs' 43 shots have found the back of the net. They failed to have a shot in the second half of the reverse fixture in Germany.
Copenhagen v Leicester
4 - And they have Riyad Mahrez to thank. The Algeria star has been directly involved in four of Leicester's five Champions League goals, scoring three times and claiming an assist.
0 from 24 - Dinamo Zagreb have lost 21 of their last 24 Champions League games, failing to keep a clean sheet in all of those 24 games and conceding a massive 63 goals in the process.
3 - Club Brugge have given away more penalties than any other team in the competition thus far (three); one of those includes Andre Silva's injury-time winner for Porto last time out.
