Cristiano Ronaldo was left out of the Real Madrid squad to play Hercules at the Bernabeu on Saturday to give him more time to recover from a muscle strain.
The Portugal forward missed last week's win at Racing Santander, but is likely to be ready for Wednesday's Champions League last-16 second leg against Olympique Lyon.
Hercules have included Paraguay striker Nelson Valdez in their squad at the player's request, coach Esteban Vigo said, after having missed their last five matches with injury.
Valdez is the only Hercules player to have scored away from home, bagging all three goals for La Liga's worst travellers.
"It will be difficult, but it also was at the Nou Camp and we managed to win there," Vigo told reporters, referring to their 2-0 win over Barca last September.
"It's possible (Barca could be tired after playing Arsenal midweek), above all if the result is against them and they have to make an extra effort," Sevilla coach Gregorio Manzano told daily Sport.
"Our objective is to score first to oblige them to make this effort. If they have their day and score first they are almost unstoppable."
"It's an important victory for the team because we haven't been doing so well in recent games," Brazilian striker Nilmar told reporters. "We needed a lift like this."
"We believe in the youngsters who are having to step in," coach Mauricio Pochettino told reporters. "In a couple of years we are going to be tremendously strong and we'll be able to look back on all this with pride."
