Injured defender Bacary Sagna has withdrawn from the France squad, with Christophe Jallet drafted in to replace him.
The Manchester City right-back has been struggling with a groin injury since the Champions League defeat to Monaco last week, but played 25 minutes as a substitute in Sunday's 1-1 home Premier League draw with Liverpool.
Sagna, 34, travelled to France's base in Clairefontaine despite being seen limping after the Liverpool match.
Christophe ( ) remplace (lésion musculaire à l'adducteur gauche). March 20, 2017
France travel to Luxembourg in World Cup qualifying on Saturday before hosting Spain in a high-profile friendly next Tuesday.
In Sagna's absence, Jallet will compete with Monaco's Djibril Sidibe for selection at right-back.
France have already lost Manchester United midfielder Paul Pogba from their initial squad for the double-header through injury, with Tiemoue Bakayoko replacing him.
