The Milan outfit suffered two defeats to Atalanta last season, including a thrilling 4-3 reverse at San Siro in April, and drew both meetings in the 2011-12 campaign.
Their last success came in a 3-1 home win more than three years ago, with goals from Diego Milito, Sulley Muntari and Christian Chivu securing the points on that occasion.
Inter go into Tuesday's game at the Stadio Atleti Azzurri d'Italia on the back of a 4-2 home victory over Verona.
That triumph ended a run of three Serie A matches without a win for Walter Mazzarri's side, and left them fourth with 18 points from nine games.
"It is another test for us to see how far we've come," he said. "The next two games (against Atalanta and Udinese) will tell us a lot about where we are going.
"I'm delighted with the way the lads have taken everything on board. I look not just at the results but how we play and I'm happy."
