New Milan coach Clarence Seedorf claimed a home victory over Verona in his first match in charge last week, and the San Siro giants - who are languishing in 11th place in the table - visit Sardinia looking to record consecutive top-flight wins for the first time since May last year.
Cagliari are in turmoil off the pitch, with owner Massimo Cellino indicating that more players, such as highly-rated defender Davide Astori, could follow Radja Nainggolan out of their temporary home the Stadio Sant'Elia after their star midfielder joined Roma earlier this month.
Ivo Pulga's 14th-placed side have gone five Serie A matches without a win, but victory over the inconsistent Milan - who lost 2-1 at home to Udinese in the Coppa Italia last eight on Wednesday - would move them to within a point of their opponents.
However, Cagliari have not beaten Milan in their last 22 matches in all competitions - a run that stretches all the way back to October 1998.
