The pre-season title favourites will battle for the first time this term at the Juventus Stadium with at least one 100 per cent winning record sure to end.
Defending champions Juve, who sit top on goal difference, have dominated in recent seasons, winning three straight league titles under the stewardship of Antonio Conte - including last season as they finished 17 points ahead of Roma.
But it would be foolhardy to see Sunday's clash as a foregone conclusion, with Roma having shown a dramatic improvement under Rudi Garcia in the last 16 months.
Part of Roma's success is down to the performances of evergreen captain Francesco Totti, who this week became the oldest goalscorer in UEFA Champions League history with the equaliser in their impressive 1-1 draw at Manchester City.
The 38-year-old is well aware that Roma's early-season form counts for nothing yet, though.
"The problem is that we have not won anything yet," he told La Repubblica. "We have experienced some beautiful moments, but in the end what counts is the result."
Juve skipper Giorgio Chiellini was in equally bullish mood ahead of the intriguing contest and he insists Sunday's result has no bearing on the destination of the Serie A title.
"The game won't determine anything given that it's still early days," he told Sky Sport Italia.
"We've both begun the campaign in good form and it'll be a tense match where it's vital we take our chances."
Juve, who are looking to bounce back from Wednesday's 1-0 Champions League loss at Atletico Madrid, are once more without Andrea Barzagli (heel) who will visit a specialist in the coming days.
