Portugal played their quarter-final against Czech Republic on Thursday, while Spain's last-eight match against France was on Saturday and Minano said that would give the Portuguese "something of an advantage" over the holders in Donetsk.
"There is no doubt that it has an impact but then again we had a day longer than the French to prepare for the quarter-final so we can't use it as an excuse either," he added in a rare appearance at a news conference at Spain's training base in Gniewino, northern Poland.
"A few years ago it was unthinkable that a player could play 5,000 minutes of football in a season, which is the case with some of these footballers," he added.
"It's a challenge for them no doubt but it's the same for other teams and the response has been good.
"Based on that response, the coach is picking the players who he believes can perform the best."
"The calm and the excellent facilities we have found here [in Gniewino] will certainly play a major role in the decision," he said.
