The defending champions are already assured of their place in the round of 16 and only a Basel victory by four goals or more could jeopardise Real's chances of topping Group B.
Real currently sit six points clear of their Swiss opponents and claimed a 5-1 triumph when the sides met at Santiago Bernabeu back in September.
Carlo Ancelotti's men will head into this week's clash having embarked on a winning streak of 14 matches in all competitions.
However, in Basel, Ancelotti - who this week revealed talks over a new contract have started - faces a side who have won both home fixtures in the Champions League so far, beating Liverpool 1-0 and Ludogorets 4-0.
If Basel get the better of Real and Liverpool fail to beat Ludogorets, the Swiss champions will join Ancelotti's side in the next round.
And coach Paulo Sousa - whose last Champions League appearance as a player was against Real Madrid with Panathinaikos - will have been boosted this week by the news that captain Marco Streller has put pen to paper on a new deal that will keep him at the club until 2016.
Less encouraging for Basel is the fact that when they last hosted Spanish opposition in the Champions League - Barcelona in 2008 - they were on the receiving end of a 5-0 thumping, although they did beat Valencia 3-0 on home soil during last season's UEFA Europa League.
Real continue to make do without Luka Modric, who was injured in Croatia's 1-1 draw with Italy during the international break, with Isco the man chosen to step into the void for Saturday's 4-0 victory over Eibar.
