Valdes had to be withdrawn 10 minutes from time in Spain's 1-0 defeat against South Africa in Johannesburg on Tuesday after being introduced as a half-time substitute.
Spanish champions Barca have confirmed that the 31-year-old is set to sit out their next eight games, with veteran stopper Jose Manuel Pinto expected to deputise in his absence.
A statement on the club's official website said: "As communicated by the club medical services, tests confirmed Wednesday that Victor Valdes has a proximal myotendinous rupture in the medial gastrocnemius of the right leg.
"The approximate time low is around six weeks."
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