Arsenal's 3-1 win over Everton was not enough to secure Champions League qualification and, to make matters worse, Arsene Wenger faces a potential selection crisis ahead of the FA Cup final.
Alexis Sanchez, Laurent Koscielny and Gabriel could all miss Saturday's Wembley clash with Premier League champions Chelsea following a desperately disappointing day for the Gunners at Emirates Stadium, despite their victory.
Following Hector Bellerin's early opener, Koscielny was shown a straight red card for a wild lunge on Enner Valencia and, after Sanchez had doubled the lead, Gabriel was taken off on a stretcher with a left knee injury after an awkward fall.
Sanchez then hobbled off midway through the second half, in what may yet prove a further blow to Arsenal's hopes of salvaging something from their season.
Everton have the ball in the net but it's ruled out for Valencia's foulMeanwhile, we make our final substitution... 2-1 (67) May 21, 2017
Aaron Ramsey's superb 91st-minute strike at least enabled Wenger's men to finish their league campaign on a stylish note, after Romelu Lukaku had halved Everton's two-goal deficit with a penalty - the Belgian's 25th Premier League strike of the season.
However, after taking their place at European club football's top table in each of the past 19 seasons, Arsenal end 2016-17 in fifth after Liverpool overcame Middlesbrough 3-0 to seal the all-important fourth place. Everton finish seventh in Ronald Koeman's first campaign in charge.
Arsenal were hanging on prior to their third goal, but began the match brightly and were ahead as Mesut Ozil combined with Ramsey and found space on the left byline, where he squared for Danny Welbeck.
The striker somehow contrived to send the ball away from goal from three yards, but his blushes were spared as it fell perfectly for Bellerin to rifle home into the unguarded net.
The Gunners suffered a setback just six minutes later, though, with Koscielny dismissed for his reckless challenge as Valencia raced away down the right.
Koeman introduced Ross Barkley in place of Tom Davies to exploit the extra space available, but within two minutes Arsenal doubled their advantage with another touch of fortune.
Sanchez's shot from outside the box struck Welbeck and, as the Everton defence appeared to stop, the forward had time to tee up Sanchez to tap home with Joel Robles stranded.
EL NINO MARAVILLA! 2-0 (27) May 21, 2017
Everton looked more dangerous as the interval approached - four players going close in a mad scramble in the 38th minute before Petr Cech made an excellent save to keep out Lukaku's header.
The Belgian sent a weak header straight at Cech soon after the resumption, before Robles excelled with a double save to deny Welbeck and Ozil.
Gabriel then departed on a stretcher to deepen Arsenal's defensive crisis, Per Mertesacker entering the fray for his first action of the season. His first start could well come against Chelsea at Wembley in six days.
Arsenal felt the numbers should have been evened up when Ashley Williams - already booked - escaped a second yellow for a trip on Welbeck and Everton were soon back in it when Rob Holding inexplicably handled Leighton Baines' harmless cross and Lukaku clinically converted the resulting penalty.
Robles denied Ozil and substitute Alex Iwobi but he could do nothing about Ramsey's sublime curling effort in stoppage time as a troubling day for Wenger at least ended on a positive note.
