The bookies make the former Old Trafford star 8/1 to net with a free-kick, or alternatively 5/2 to get a yellow card, 33/1 to be sent off and 8/1 to receive a card for a challenge on England team-mate Wayne Rooney.
The 34-year-old faces Sir Alex Ferguson's side for the first time since leaving the Red Devils for Real Madrid in 2003.
"The prospect of Beckham locking horns with Fergie has prompted a surge in interest. He remains one of the biggest draws in world sport and that translates itself into huge betting turnover," said David Williams of Ladbrokes.
"We're laying plenty of United but would much prefer to be laying Milan. We'll be cheering on the Italians at this rate," he added.
8/5 Milan
6/4 United
2/1 Draw
4/1 To score
5/2 To be booked
33/1 To be sent-off
8/1 To be booked or sent-off for a foul on Wayne Rooney
50/1 To score an own goal
8/1 To score a free-kick
6/1 To score from outside the box
33/1 To score a 2+goals
33/1 To score a header
12/1 To hit the woodwork
100/1 To score from inside his own half
