The bookies make the former Old Trafford star 8/1 to net with a free-kick, or alternatively 5/2 to get a yellow card, 33/1 to be sent off and 8/1 to receive a card for a challenge on England team-mate Wayne Rooney.
The 34-year-old faces Sir Alex Ferguson's side for the first time since leaving the Red Devils for Real Madrid in 2003.
And although the ex-England captain is not guaranteed to start the match, bookmakers have gone into overdrive with markets for the LA Galaxy man.
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"The prospect of Beckham locking horns with Fergie has prompted a surge in interest. He remains one of the biggest draws in world sport and that translates itself into huge betting turnover," said David Williams of Ladbrokes.
United are the narrow 6/4 favourites for the clash in Milan, with the hosts at 8/5.
"We're laying plenty of United but would much prefer to be laying Milan. We'll be cheering on the Italians at this rate," he added.
Latest Ladbrokes betting:
8/5 Milan
6/4 United
2/1 Draw
David Beckham Specials
4/1 To score
5/2 To be booked
33/1 To be sent-off
8/1 To be booked or sent-off for a foul on Wayne Rooney
50/1 To score an own goal
8/1 To score a free-kick
6/1 To score from outside the box
33/1 To score a 2+goals
33/1 To score a header
12/1 To hit the woodwork
100/1 To score from inside his own half
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