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New signings Bruno Guimaraes, Matt Targett and Dan Burn could be handed Newcastle debuts against Premier League rivals Everton on Tuesday evening.
Former Lyon midfielder Guimaraes and on-loan Aston Villa full-back Targett are in contention, while central defender Burn, who joined the Magpies from Brighton on deadline day, is battling an infected toenail as he bids to join them.
New signings Dele Alli and Donny Van De Beek will be in Everton’s squad for the first time.
The pair were both cup-tied for the FA Cup fourth-round win over Brentford at the weekend.
Striker Dominic Calvert-Lewin, who missed that game with a knee problem, returns but defender Ben Godfrey has been ruled out for four to five weeks with a hamstring injury.
Newcastle provisional squad: Dubravka, Darlow, Gillespie, Manquillo, Trippier, Murphy, Targett, Krafth, Burn, Schar, Lascelles, Shelvey, Guimaraes, S. Longstaff, Willock, Fraser, Almiron, Joelinton, Saint-Maximin, Wood, Gayle.
Everton provisional squad: Pickford, Coleman, Mina, Keane, Holgate, Mykolenko, Allan, Van De Beek, Richarlison, Calvert-Lewin, Alli, Begovic, Kenny, Patterson, Branthwaite, Gomes, Gbamin, Townsend, Gray, Tosun, Iwobi.
