The 21-year-old has netted 44 league goals in 117 appearances for the club since arriving from Independiente in 2006.
The Argentina international - who has won 20 caps for his country - was strongly linked with a switch away from Spain during the close-season, with Chelsea, United and Inter all tipped to make big-money moves for the rojiblancos' star.
And after Atletico's poor start to the campaign - which has already seen coach Abel Resino sacked - further reports have surfaced suggesting Chelsea will renew their interest in the talisman, pending an appeal against a transfer ban imposed by FIFA.
The player's agent, Jose Segui, recently did little to quash talk of the forward departing, after revealing he is not aware of the current situation regarding a possible move.
And former Vicente Calderon striker Cano - who lifted the la Liga title with Atletico in 1977 - believes the Argentine will soon leave the club in search of silverware with another side.
"He is at Atletico. If he was at another team, I'm sure he would be very effective, very pro-active," he told AS.
"There are lots of options for Aguero to stop being tired [of a lack of success] by leaving Atletico.
"At the end of the day, players have their personal pride. They talk amongst themselves and ask 'What have you won?'
"And Aguero will see that he has won nothing and he will leave."
