Serie C side Botafogo PB held on for a 0-0 draw at Goias' Estadio do Governo do Estado de Goias for a 2-0 aggregate win.
The Serie A outfit were unable to find a goal and had substitute Carlos Alberto sent off after picking up two yellow cards in the second half.
Top-flight outfit Coritiba needed two second-half goals to overcome CENE 2-0 and 4-2 on aggregate at the Estadio Major Antonio Couto Pereira.
Julio Cesar and Carlinhos struck after the hour-mark to see Celso Roth's men to the hard-fought win.
Santos overcame Mixto 3-0 thanks to three goals in the final half-hour, including a brace from Gabriel.
Paysandu edged Maranhao 2-1 at home in a thrilling tie which saw them advance 4-3 on aggregate.
Leandro Carvalho scored the decisive goal in the 72nd minute to send his side into the next round.
Caldense completed a 4-2 aggregate win over Duque de Caxias after securing a 2-2 draw away from home.
Cuiaba got past Barbalha 2-0 after their first leg ended scoreless.
The tie between Bahia and Villa Nova was postponed and remains locked at 1-1 on aggregate.
Internacional crushed Remo 6-1 in the first leg so did not have to play a second, while Corinthians had also sealed their progression.
Avai had thrashed Naviraiense 4-1 so also did not require a return leg, neither did Chapecoense against Rio Branco.
In a first-leg clash, Princesa Solimoes were 3-1 victors at home to Brasiliense.
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