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Daniele De Rossi will miss Roma's Champions League trip to CSKA Moscow, head coach Eusebio Di Francesco confirmed.
De Rossi was injured in the first half of Roma's last match, a 1-1 draw away to Napoli, in what was his 450th Serie A appearance.
And the club captain will miss Saturday's trip to Fiorentina as well as the Group G game away to CSKA four days later.
"De Rossi won't be involved against Fiorentina or CSKA - and he may miss the Sampdoria game too," Di Francesco told a news conference.
SQUAD LIST | | v. Fiorentina (a)Daniele De Rossi does not travel, but Kostas Manolas, Justin Kluivert and Javier Pastore are all available. November 2, 2018
Roma, who reached the semi-finals of the Champions League last season, are level on points with Real Madrid after two wins from three Group G matches.
Di Francesco's side are struggling in Serie A, however, sitting eighth in the table after failing to win either of their most recent two games.
